Geodesic regression generalizes linear regression to general Riemannian manifolds. Applied to images, it allows for a compact approximation of an image time-series through an initial image and an initial momentum. Geodesic regression requires the …
Current longitudinal image registration methods rely on the assumption that image appearance between time-points remains constant or changes uniformly within intensity classes. This assumption, however, is not valid for magnetic resonance imaging of …
The human cerebral cortex is one of the most complicated structures in the body. It has a highly convoluted structure with much of the cortical sheet buried in sulci. Based on cytoarchitectural and functional imaging studies, it is possible to …
Localized difference in the cortex is one of the most useful morphometric traits in human and animal brain studies. There are many tools and methods already developed to automatically measure and analyze cortical thickness for the human brain. …
Registration of image-time series has so far been accomplished (i) by concatenating registrations between image pairs, (ii) by solving a joint estimation problem resulting in piecewise geodesic paths between image pairs, (iii) by kernel based local …
. Standard image registration methods do not account for changes in image appearance. Hence, metamorphosis approaches have been developed which jointly estimate a space deformation and a change in image appearance to construct a spatio-temporal …
The analysis of neuroimaging data from pediatric populations presents several challenges. There are normal variations in brain shape from infancy to adulthood and normal developmental changes related to tissue maturation. Measurement of cortical …
Chorea-acanthocytosis (ChAc) is an uncommon autosomal recessive disorder due to mutations of the VPS13A gene, which encodes for the membrane protein chorein. ChAc presents with progressive limb and orobuccal chorea, but there is often a marked …
Frontostriatal circuit mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD) and may differ across subtypes of FTLD. We manually segmented the neostriatum (caudate nucleus and putamen) in FTLD subtypes: …
This paper proposes a new method to compute connectivity information from diffusion weighted images. It is inspired by graph-based approaches to connectivity definition, but formulates the estimation problem in the continuum. In particular, it …